Commercial Supply Ensitrelvir (S-217622) Intermediates:
S-Ethylisothiourea Hydrobromide CAS 1071-37-0
2,4,5-Trifluorobenzyl Bromide CAS 157911-56-3
Trimethyloxonium Tetrafluoroborate CAS 420-37-1
6-Chloro-2-methyl-2H-indazol-5-amine CAS 1893125-36-4
3-(Chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride CAS 135206-76-7
1,3,5-Triazine-2,4(1H,3H)-dione, 3-(1,1-dimethylethyl)-6-(ethylthio)- CAS 1360105-53-8
| Chemical Name | 2,4,5-Trifluorobenzyl Bromide |
| Synonyms | 1-(Bromomethyl)-2,4,5-trifluorobenzene |
| CAS Number | 157911-56-3 |
| CAT Number | RF-PI1505 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C7H4BrF3 |
| Molecular Weight | 225.01 |
| Flash Point | 75℃ |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Colorless to Light Yellow Clear Liquid |
| Purity / Analysis Method | >98.0% (GC) |
| Moisture (K.F) | ≤0.50% |
| Specific Gravity (20/20) | 1.714~1.719 |
| Refractive Index (N20/D) | 1.505~1.509 |
| Total Impurities | <2.00% |
| Infrared Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediates |
Package: Bottle, 25kg/Barrel, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
2,4,5-Trifluorobenzyl Bromide (CAS: 157911-56-3) is mainly used in pharmaceutical industry as a pharmaceutical intermediate. 2,4,5-Trifluorobenzyl Bromide is an important intermediate in the synthesis of Sitagliptin (CAS: 486460-32-6). 2,4,5-Trifluorobenzyl Bromide is also an important intermediate of Ensitrelvir (S-217622). Ensitrelvir, a therapeutic drug for COVID-19, is a 3CL protease inhibitor created through joint research between Hokkaido University and Shionogi. SARS-CoV-2 has an enzyme called 3CL protease, which is essential for the replication of the virus. Ensitrelvir suppresses the replication of SARS-CoV-2 by selectively inhibiting 3CL protease.