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Commercial Supply Palonosetron Hydrochloride and Related Intermediates:
1,2,3,4-Tetrahydro-Naphthoic Acid CAS: 1914-65-4
(S)-1,2,3,4-Tetrahydro-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API
| Chemical Name | (S)-3-Aminoquinuclidine Dihydrochloride |
| Synonyms | (S)-(-)-3-Aminoquinuclidine 2 HCL |
| CAS Number | 119904-90-4 |
| CAT Number | RF-CC112 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C7H16Cl2N2 |
| Molecular Weight | 199.12 |
| Solubility in Water | Soluble |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Light Yellow Crystalline Powder |
| IR | Absorption Spectra Consistent with the Reference |
| Chloride Reaction | Positive Reaction |
| Purity | ≥98.0% |
| Loss on Drying | ≤0.50% |
| Specific Rotation [α]D20 | -22.0°~ -26.0° (C=1, H2O) |
| Heavy Metals | ≤20ppm |
| Storage | 5-8℃ Airtightness |
| Test Standard | Enterprise Standard |
| Usage | Palonosetron Hydrochloride (CAS: 135729-62-3) Intermediates |
(S)-3-Aminoquinuclidine Dihydrochloride (CAS: 119904-90-4) Synthetic Route
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-3-Aminoquinuclidine dihydrochloride (CAS: 2133-40-6) with high quality. It is a pharmaceutical intermediate typically in the synthesis of Palonosetron Hydrochloride (CAS: 135729-62-3).
Palonosetron Hydrochloride (CAS: 135729-62-3) is a drug to inhibit nausea and vomiting, which is a new type highly selective, high-affinity 5-HT3 receptor antagonist that can block the vomiting reflex center peripheral neurons presynaptic 5-HT. Receptor excitement directly affects the central nervous system in 5-HT. Impulse receptor excitement generated by the role of vagal afferent nerve after area, blocking the vagus nerve endings in the gut, preventing signals to 5-HT. Receptor trigger zone can reduce the incidence of nausea and vomiting. Central clinically for the treatment of acute severe emetogenic chemotherapy induced delayed nausea and vomiting. Because of its high curative effect, little side effect, long half-life (about 40 h), small dosage, and so on, it has attracted much attention. With 1,2,3,4-tetrahydro-1-naphthoic acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron. Clinical studies showed that palonosetron can be used safely with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugsas the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
