Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 2-(Trimethylsilyl)ethanol (CAS: 2916-68-9) with high quality. Ruifu Chemical has been supplying 2-(Trimethylsilyl)ethanol more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase 2-(Trimethylsilyl)ethanol or other products, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | 2-(Trimethylsilyl)ethanol |
| Synonyms | (2-Hydroxyethyl)trimethylsilane; 2-(Trimethylsilanyl)ethanol; 2-(Trimethylsilyl)ethyl Alcohol; β-(Trimethylsilyl)ethanol |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 2916-68-9 |
| Molecular Formula | C5H14OSi |
| Molecular Weight | 118.25 g/mol |
| Boiling Point | 71.0-73.0℃/35 mmHg (lit.) |
| Flash Point | 123°F |
| Density | 0.825 g/mL at 25℃(lit.) |
| Refractive Index n20/D | 1.423 (lit.) |
| Store Under Inert Gas | Store Under Inert Gas |
| Sensitive | Light Sensitive, Moisture Sensitive |
| Hydrolytic Sensitivity | 4: No Reaction with Water Under Neutral Conditions |
| Storage Temperature | Store Long-Term at 2-8℃, Refrigerator, Under Inert Atmosphere |
| Shipping Conditions | Ambient |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories |
Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Colorless Transparent Liquid | Colorless Transparent Liquid |
| Density (20℃) | 0.825-0.830 | Conforms |
| Refractive Index n20/D | 1.423-1.425 | Conforms |
| Water by Karl Fischer | ≤0.50% | 0.11% |
| Assay / Analysis Method | ≥98.0% (GC) | 99.37% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
| Preservation Conditions | 2-8℃, ventilated, dry, dark, sealed, nitrogen protection extend the shelf life. | |
Package: Fluorinated bottle, 25kg/drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃), dark and well-ventilated warehouse away from incompatible substances. Keep away from heat, sparks, and flame. Flammables-area.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Risk Codes R10 - Flammable
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S16 - Keep away from sources of ignition.
S37/39 - Wear suitable gloves and eye/face protection
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24/25 - Avoid contact with skin and eyes.
UN IDs UN 1987 3/PG 3
WGK Germany 3
RTECS KM5480000
TSCA No
HS Code 2931900090
Hazard Note Flammable
Hazard Class 3
Packing Group III
Protecting Group Chemistry
One of the most prominent applications of 2-(Trimethylsilyl)ethanol is as a protecting group in organic synthesis.
Hydroxyl (OH) Protection: TMSE can be used to temporarily protect hydroxyl groups in molecules, allowing for selective modification of other functional groups without affecting the OH group. This is particularly useful in complex molecule synthesis where specific functionalities need to be targeted.
Carboxyl (COOH) Protection: Similar to hydroxyl groups, 2-(Trimethylsilyl)ethanol can also protect carboxylic acid functionalities present in molecules. This allows for further manipulations without affecting the COOH group.
Amino (NH2) and Phosphoryl (PO4) Protection: Although less common, TMSE can also be used to protect amino and phosphoryl groups under specific reaction conditions.
The advantage of using 2-(Trimethylsilyl)ethanol as a protecting group lies in its ease of introduction and removal under mild reaction conditions. This makes it a valuable tool for chemists to achieve selective modifications in complex molecules.
Precursor Synthesis
2-(Trimethylsilyl)ethanol can serve as a precursor for the synthesis of other valuable compounds:
Trimethylsilyl (TMS) Derivatives: TMSE reacts with aromatic fluorides to form trimethylsilyl derivatives, which are useful intermediates in various organic transformations.
Teoc-Protected Amines: By reacting with isocyanates, 2-(Trimethylsilyl)ethanol can be used to synthesize teoc-protected amines. These protected amines are valuable building blocks in peptide synthesis and other applications.