Manufacturer Supply Deoxynucleosides Intermediates with High Purity and Stable Quality
| 2'-Deoxyguanosine monohydrate CAS: 961-07-9 |
2'-Deoxyadenosine CAS: 958-09-8 |
| 2'-Deoxyuridine CAS: 951-78-0 |
2'-Deoxycytidine CAS: 951-77-9 |
| 5-Iodo-2'-Deoxyuridine CAS: 54-42-2 |
|
| Chemical Name |
2'-Deoxycytidine |
| CAS Number |
951-77-9 |
| CAT Number |
RF-PI206 |
| Stock Status |
In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula |
C9H13N3O4 |
| Molecular Weight |
227.22 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White or Almost White Crystalline Powder |
| Heavy Metals |
≤20ppm |
| Loss on Drying |
≤0.50% |
| Residue on Ignition |
≤0.20% |
| Purity / Analysis Method |
≥99.0% (HPLC) |
| Test Standard |
Enterprise Standard |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
2-Deoxycytidine is a cytidine analog. 2′-Deoxycytidine is a deoxyribonucleoside as Eg5 kinesin modulator with apoptosis-inducing and antiproliferative activity.
2-Deoxycytidine prevents DNA methylation by incorporating itself into newly synthesizing DNA strand. 2-Deoxycytidine also binds to DNA methyltransferase irreversibly and hinders its activity. Thus, 2-deoxycytidine was approved as the most efective demethylating agent for the treatment of cancer .
2-Deoxycytidine at clinically achievable and nontoxic concentrations (≥ 100 μmol/L) protected normal bone marrow progenitor cells against the inhibitory effects of co-administered, high concentrations of 3’-azido-3’-deoxythymidine (AZT) (≥ 10 μmol/L). In normal bone marrow mononuclear cells (BMMC), 2-deoxycytidine also significantly corrected AZT-mediated depletion of intracellular thymidine triphosphate and 2-deoxycytidine triphosphate levels. Furthermore, 2-deoxycytidine reduced the intracellular accumulation of AZT triphosphate and its DNA incorporation in BMMC.