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Tipiracil Hydrochloride (CAS: 183204-72-0) Related Intermediates
6-(Chloromethyl)uracil CAS: 18592-13-7
6-(Hydroxymethyl)uracil CAS: 22126-44-9
2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4
| Chemical Name |
2-Amino-1-Pyrroline Hydrochloride |
| Synonyms |
3,4-Dihydro-2H-Pyrrol-5-Amine Hydrochloride; 2-Aminopyrrolidine HCl |
| CAS Number |
7544-75-4 |
| CAT Number |
RF-PI1838 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C4H8N2·HCl |
| Molecular Weight |
120.58 |
| Melting Point |
171.0 to 175.0℃ |
| Sensitive |
Hygroscopic |
| Brand |
Ruifu Chemical |
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Item
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Specifications
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Results
|
|
Appearance
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White Powder
|
White Powder
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Purity / Analysis Method
|
>99.5% (HPLC)
|
99.8%
|
|
Largest Single Impurity
|
<0.50%
|
0.09%
|
|
Water Content (K.F)
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<0.50%
|
0.45%
|
|
Proton NMR Spectrum
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Conforms to Structure
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Conforms
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Test Standard
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Enterprise Standard
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Usage
|
Intermediate of Tipiracil Hydrochloride (CAS: 183204-72-0)
|
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture
2-Amino-1-Pyrroline Hydrochloride (CAS: 7544-75-4) is a heterocyclic organic compound, which can be used as a pharmaceutical intermediate. 2-Amino-1-Pyrroline Hydrochloride is an intermediate of Tipiracil Hydrochloride (CAS: 183204-72-0) in the treatment of Rectal Cancer. Tipiracil Hydrochloride is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine, a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.