Supply Bortezomib Related Intermediates with High Purity
(1S,2S,3R,5S)-(+)-2,3-Pinanediol CAS 18680-27-8
(1R,2R,3S,5R)-(-)-2,3-Pinanediol CAS 22422-34-0
Bortezomib CAS 179324-69-7
| Chemical Name | (1S,2S,3R,5S)-(+)-2,3-Pinanediol |
| Synonyms | (1S,2S,3R,5S)-2,6,6-Trimethylbicyclo[3.1.1]heptane-2,3-diol |
| CAS Number | 18680-27-8 |
| CAT Number | RF-CC290 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C10H18O2 |
| Molecular Weight | 170.25 |
| Solubility | Chloroform, Toluene |
| Shipping Condition | Shipped Under Ambient Temperature |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Off-White Crystallized Powder |
| Melting Point | 56.0~59.0℃ |
| Loss on Drying | ≤0.50% |
| Residue on Ignition | ≤0.50% |
| Enantiomeric Excess | e.e≥99.0% |
| Purity / Analysis Method | ≥99.0% (GC) |
| Specific Rotation [α]20/D | +8.5° to +9.5° (C=6.5, Toluene) |
| Infrared Spectrum | Conforms |
| Test Standard | Enterprise Standard |
| Usage | Chiral Compounds; Pharmaceutical Intermediates; Bortezomib Intermediate |
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (1S,2S,3R,5S)-(+)-2,3-Pinanediol (CAS 18680-27-8) with high quality, widely used in organic synthesis, synthesis of pharmaceutical intermediates and fine chemical synthesis.
Shanghai Ruifu Chemical Co., Ltd. plays an important role in the chiral chemistry, the company is committed to the production of chiral compounds. Our products are widely praised by customers.
(1S,2S,3R,5S)-(+)-2,3-Pinanediol (CAS 18680-27-8), is a useful Chiral reagent used in the synthesis of homochiral α-hydroxyketones and in the resolution of prolineboronate esters. It is also a useful precursor to a chiral allyl boronate used in a preparation of chiral β-hydroxyallylsilanes.
(1S,2S,3R,5S)-(+)-2,3-Pinanediol (CAS 18680-27-8) is an Intermediate of Bortezomib (CAS 179324-69-7) in the treatment of Multiple Myeloma. Bortezomib, a potent ubiquitin proteasome (26S) inhibitor (Ki=0.6 nM), was launched in the US as a treatment for multiple myeloma. This proteasome is required for the proteolytic degradation of the majority of cellular proteins and is present in all cells. It is required for the control of inflammatory processes, cell cycle regulation and gene expression and is a novel target in cancer treatment.