Manufacturer Supply, High Purity, Commercial Production
Chemical Name: 2-Chloroadenine
CAS: 1839-18-5
| Chemical Name |
2-Chloroadenine |
| Synonyms |
6-Amino-2-Chloropurine; Cladribine EP Impurity B |
| CAS Number |
1839-18-5 |
| CAT Number |
RF-PI513 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C5H4ClN5 |
| Molecular Weight |
169.57 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
Yellowish to Off-White Powder |
| Assay / Analysis Method |
≥98.0% (HPLC) |
| Melting Point |
≥300℃ |
| Loss on Drying |
≤0.50% |
| Residue on Ignition |
≤0.50% |
| Heavy Metals (as Pb) |
≤0.001% |
| Total Impurities |
≤2.0% |
| Test Standard |
Enterprise Standard |
| Usage |
Intermediate of Clofarabine (CAS: 123318-82-1), Cladribine (CAS: 4291-63-8) |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.
2-Chloroadenine (CAS: 1839-18-5) is mainly used as intermediate of Clofarabine (CAS: 123318-82-1), Cladribine (CAS: 4291-63-8) and other APIs. Clofarabine is a novel purine nucleoside anticancer drugs is first successfully developed by the Top10 biopharmaceutical company of the United States-Genzyme Corporation. On December 28, 2004 the US food and Drug Administration (FDA) used fast-track for approval of clofarabine for application to children with refractory or relapsed acute lymphocytic leukemia. Cladribine (2-chloro-2′-deoxyadenosine) is an adenosine deaminase-resistant analogue of deoxyadenosine. The drug has a broad range of in vitro activity against both lymphoid and myeloid neoplasms.