Commercial Supply Solifenacin Succinate Related Intermediates:
Solifenacin Succinate CAS: 242478-38-2
(R)-(-)-3-Quinuclidinol CAS: 25333-42-0
(S)-(+)-3-Quinuclidinol CAS: 34583-34-1
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Phenyl-1,2,3,4-Tetrahydro-Isoquinoline CAS: 22990-19-8
(S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline CAS: 118864-75-8
| Chemical Name |
1-Phenyl-1,2,3,4-Tetrahydroisoquinoline |
| Synonyms |
1,2,3,4-Tetrahydro-1-Phenylisoquinoline |
| CAS Number |
22990-19-8 |
| CAT Number |
RF-PI155 |
| Stock Status |
In Stock, Production Scale Up to Tons |
| Molecular Formula |
C15H15N |
| Molecular Weight |
209.29 |
| Brand |
Ruifu Chemical |
| Item |
Specifications |
| Appearance |
White Crystal Powder |
| Single Impurity |
≤0.20% |
| Melting Point |
93.0~99.0℃ |
| Loss on Drying |
≤0.50% |
| Assay |
≥98.5% (HPLC) |
| Assay |
98.5%~101.0% (on the dried basis) |
| Test Standard |
Enterprise Standard |
| Usage |
Solifenacin Succinate (CAS: 242478-38-2) Intermediate |
Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Solifenacin Succinate (CAS: 242478-38-2) is an antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, or incontinence. Solifenacin Succinate (CAS: 242478-38-2) is an M3 muscarinic receptor antagonist that was developed and launched for the treatment of overactive bladder (pollakiuria) in Europe. The synthesis of solifenacin involves the preparation of racemic 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline via cyclization of N-(2-phenylethyl)benzamide, and subsequent reaction with ethyl chloroformate and transesterification with (R)- 3-Quinuclidinol. Chiral chromatography affords the isolation of the desired diastereomer. Alternatively, 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline may be subjected to optical resolution with (+)-Tartaric Acid prior to treatment with ethyl chloroformate and subsequent transesterification.