Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 1-Boc-3-(Cyanomethylene)azetidine (CAS: 1153949-11-1) with high and stable quality control, an important intermediate of Baricitinib (CAS: 1187594-09-7).
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available.
Purchase Baricitinib intermediates, Please contact us by e-mail: alvin@ruifuchem.com for quotation requests. Please provide quantity, purity, and any other specific requirements.
| Chemical Name | 1-Boc-3-(Cyanomethylene)azetidine |
| Synonyms | 1-(tert-Butoxycarbonyl)-3-(Cyanomethylene)azetidine; tert-Butyl 3-(Cyanomethylene)azetidine-1-Carboxylate; 3-(Cyanomethylene)azetidine-1-Carboxylic Acid tert-Butyl Ester; Baricitinib Impurity 10 |
| Stock Status | In Stock, Commercial Production |
| CAS Number | 1153949-11-1 |
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.23 g/mol |
| Density | 1.215 |
| Store Under Inert Gas | Store Under Inert Gas (Nitrogen or Argon) at 2~8℃ |
| Sensitive | Air Sensitive, Heat Sensitive |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories |
Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White to Light-Yellow Solid Powder | Light-Yellow Solid Powder |
| Water by Karl Fischer | <0.50% | 0.21% |
| Purity / Analysis Method | >98.0% (HPLC Area) | 99.5% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| 1H NMR Spectrum | Conforms to Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
| Usage | Intermediate in the Synthesis of Baricitinib (CAS: 1187594-09-7) | |
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Air Sensitive, heat sensitive. Store under inert gas. Keep the container tightly closed and store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
UN IDs UN 3439 6.1/PG III
Hazard Class 6.1
Packing Group III
HS Code 2933990099
1-Boc-3-(Cyanomethylene)azetidine (CAS: 1153949-11-1) is an important intermediate in the synthesis of Baricitinib (CAS: 1187594-09-7). Baricitinib is used for the treatment of moderately to severely active rheumatoid arthritis (RA) in adults, patients who are intolerant of one or more anti-rheumatic drugs can be treated with this product. This product can be used as a single drug or in combination with methotrexate. combination therapy. Baricitinib, sold under the brand name Olumiant among others, is a drug for the treatment of rheumatoid arthritis (RA) in adults whose disease was not well controlled using RA medications called tumor necrosis factor (TNF) antagonists. It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. The drug is approved for use in the European Union and the United States.